Diagnosis of Insulinoma (2) Consequently, random plasma insulin measurements, except in the presence of chemically established hypoglycaemia, are of no diagnostic value. Plasma C-peptide levels, like those of insulin, rise after B-cell stimulation but, because of its larger pool size and slower turnover rate, large fluctuations in plasma C-peptide are less common. See also: • Diagnosis of Endogenous Hyperinsulinism • Treatment of Endogenous Hyperinsulinism • Nesidioblastosis